MovDisordV3, Main, Exploration, bibRecord, 001018

Primary Lateral Sclerosis as Progressive Supranuclear Palsy: Diagnosis by Diffusion Tensor Imaging

Identifieur interne : 001018 ( Main/Exploration ); précédent : 001017; suivant : 001019

Primary Lateral Sclerosis as Progressive Supranuclear Palsy: Diagnosis by Diffusion Tensor Imaging

Auteurs : Elizabeth A. Coon [États-Unis] ; Jennifer L. Whitwell [États-Unis] ; Clifford R. Jr Jack [États-Unis] ; Keith A. Josephs [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0280063

Descripteurs français

Pascal (Inist)
- Maladie du neurone moteur, Pathologie du système nerveux, Ophtalmoplégie supranucléaire, Diagnostic, Imagerie du tenseur de diffusion.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Anisotropy, Case-Control Studies, Corpus Callosum (pathology), Diagnosis, Diffusion Tensor Imaging, Diffusion tensor imaging, Female, Humans, Male, Middle Aged, Motor Neuron Disease (diagnosis), Motor neuron disease, Nervous system diseases, Prospective Studies, Pyramidal Tracts (pathology), Supranuclear Palsy, Progressive (physiopathology), Supranuclear ophthalmoplegia, Tegmentum Mesencephali (pathology).
MESH :
- diagnosis : Motor Neuron Disease.
- pathology : Corpus Callosum, Pyramidal Tracts, Tegmentum Mesencephali.
- physiopathology : Supranuclear Palsy, Progressive.
- Aged, Aged, 80 and over, Anisotropy, Case-Control Studies, Diffusion Tensor Imaging, Female, Humans, Male, Middle Aged, Prospective Studies.

Abstract

Background: Evaluating the integrity of white matter tracts with diffusion tensor imaging may differentiate primary lateral sclerosis from progressive supranuclear palsy. Methods: Thirty-three prospectively recruited subjects had standardized evaluations and diffusion tensor imaging: 3 with primary lateral sclerosis who presented with features suggestive of progressive supranuclear palsy, 10 with probable or definite progressive supranuclear palsy, and 20 matched controls. We compared fractional anisotropy of the corticospinal tract, superior cerebellar peduncles, and body of the corpus callosum between groups. Results: Both the primary lateral sclerosis and progressive supranuclear palsy subjects showed reduced fractional anisotropy in superior cerebellar peduncle and body of the corpus callosum compared with controls, but only primary lateral sclerosis subjects showed reductions in the corticospinal tracts. A ratio of corticospinal tract/superior cerebellar peduncle best distinguished the disorders (P <.02). Conclusions: The corticospinal tract/superior cerebellar peduncle ratio is a marker to differentiate primary lateral sclerosis from progressive supranuclear palsy.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383380

Affiliations:

Le document en format XML

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<term>Corpus Callosum (pathology)</term>
<term>Diagnosis</term>
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<term>Diffusion tensor imaging</term>
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<term>Pyramidal Tracts</term>
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<front><div type="abstract" xml:lang="en">Background: Evaluating the integrity of white matter tracts with diffusion tensor imaging may differentiate primary lateral sclerosis from progressive supranuclear palsy. Methods: Thirty-three prospectively recruited subjects had standardized evaluations and diffusion tensor imaging: 3 with primary lateral sclerosis who presented with features suggestive of progressive supranuclear palsy, 10 with probable or definite progressive supranuclear palsy, and 20 matched controls. We compared fractional anisotropy of the corticospinal tract, superior cerebellar peduncles, and body of the corpus callosum between groups. Results: Both the primary lateral sclerosis and progressive supranuclear palsy subjects showed reduced fractional anisotropy in superior cerebellar peduncle and body of the corpus callosum compared with controls, but only primary lateral sclerosis subjects showed reductions in the corticospinal tracts. A ratio of corticospinal tract/superior cerebellar peduncle best distinguished the disorders (P <.02). Conclusions: The corticospinal tract/superior cerebellar peduncle ratio is a marker to differentiate primary lateral sclerosis from progressive supranuclear palsy.</div>
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Movement Disorders (revue)

Primary Lateral Sclerosis as Progressive Supranuclear Palsy: Diagnosis by Diffusion Tensor Imaging

Primary Lateral Sclerosis as Progressive Supranuclear Palsy: Diagnosis by Diffusion Tensor Imaging

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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